MDL-27531
MDL-27531 acts functionally like a glycine agonist. MDL-27531 selectively reduces hindlimb contractions. MDL-27531 selectively reverses strychnine-induced seizures in mice. MDL-27531 inhibits pentylenetetrazol-induced seizures with an ED50 of 55 mg/kg. MDL-27531 promotes the binding of benzodiazepine antagonist Ro 15-1788 to cerebral cortex of mice without changing GABA levels. MDL-27531 can be studied in research on reflex control dysfunction.
For research use only. We do not sell to patients.
- CAS No.: 116850-44-3
- Formula: C10H11N3O2S
- Molecular Weight:237.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 116850-44-3
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Molecular Weight 237.28
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Formula C10H11N3O2S
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SMILES
O=S(=O)(C1=NN=C(C=2C=CC=CC2)N1C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kehne, J. H., et al., (1992). MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord. Neuroscience letters, 147(1), 101–105. [Content Brief]
[2]. Kehne, J. H., et al., (1992). MDL 27,531 selectively reverses strychnine-induced seizures in mice. British journal of pharmacology, 106(4), 910–916. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDL-27531 Related Classifications
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