352560-76-0
Chemical Structure
TTFB
Synonym(s): N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide
- CAS No.: 352560-76-0
- Formula:C14H15FN2OS
- Molecular Weight:278.35
IUPAC Name: N-(4-(tert-butyl)thiazol-2-yl)-3-fluorobenzamide
InChIKey: YTTAGQBQBWNSSS-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(=CS1)C(C)(C)C)C=2C=CC=C(F)C2
Biological Activity: TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.
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TTFB | 99.83% | TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC. | ||||||||||||||||||||
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Keywords
