PKC
Protein Kinase C Alpha (PKCα) is a serine/threonine kinase involved in diverse cellular processes including proliferation, differentiation, and apoptosis. It plays a critical role in signal transduction pathways downstream of G-protein-coupled receptors and receptor tyrosine kinases[1]. PKCα regulates cell survival and growth through activation of the MAPK/ERK and PI3K/AKT pathways[2]. In cancer, PKCα is often overexpressed and contributes to tumor progression, particularly in breast and prostate cancers[3]. It also modulates vascular smooth muscle contraction and endothelial function, implicating it in cardiovascular diseases. Notably, PKCα exhibits distinct functions compared to other PKC isoforms due to its unique subcellular localization and substrate specificity[4]. Targeting PKCα with selective inhibitors such as Gö6976 has shown therapeutic potential in preclinical models of cancer and inflammatory disorders[5].
References:
- [1]. Lee MJ, et al. Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial. Lancet HIV. 2026 May 27:S2352-3018(26)00059-7. [Content Brief]
- [2]. Wolf S, et al. Selection for Evi1 activation in myelomonocytic leukemia induced by hyperactive signaling through wild-type NRas. Oncogene. 2013 Jun 20;32(25):3028-38. [Content Brief]
- [3]. Ali SR, et al. Nerve Density and Neuronal Biomarkers in Cancer. Cancers (Basel). 2022 Oct 1;14(19):4817. [Content Brief]
- [4]. Kim JY, et al. The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice. Cell Signal. 2010 Nov;22(11):1669-80. [Content Brief]
- [5]. Ciglenecki I, et al. Low sensitivity of the fourth-generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural Eswatini: a diagnostic accuracy study. J Int AIDS Soc. 2025 Jul;28(7):e26517. [Content Brief]
All Product Categories
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PKC Related Products (385)
Related Products (385)
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KS 619-1
0 ImagesCat. No.: HY-114554CAS No.: 103370-21-4KS 619-1 is a Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus.
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N-Myristoyl-Lys-Arg-Thr-Leu-Arg
0 ImagesCat. No.: HY-P3083CAS No.: 125678-68-4N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC50 value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat.
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Protein kinase C α peptide TFA
0 ImagesCat. No.: HY-P3766CAS No.: 159939-84-1Protein kinase C (alpha) peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on.
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Protein Kinase C (530-558)
0 ImagesCat. No.: HY-P1288CAS No.: 122613-29-0Synonyms: PKC fragment (530-558)
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Prkd1 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11146Prkd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protein Kinase C,Rat
0 ImagesCat. No.: HY-E70949Protein Kinase C,Rat (EC 2.7.1.37) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. Protein Kinase C in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+).
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FKKSFKL-NH2
0 ImagesCat. No.: HY-P3784CAS No.: 137168-33-3FKKSFKL-NH2 is a protein kinase C-selective peptide. FKKSFKL-NH2 can be used for the research of various biochemical.
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Protein kinase C substrate
0 ImagesCat. No.: HY-P3764CAS No.: 105802-82-2Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation.
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PKC-theta inhibitor 2 hydrochloride
0 ImagesCat. No.: HY-112681BCAS No.: 2253640-49-0PKC-theta inhibitor 2 hydrochloride is a potent and selective PKC-θ inhibitor with an IC50 value of 18 nM.
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PRKCD Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11122PRKCD Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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[Ser25] Protein Kinase C (19-31)
![[Ser25] Protein Kinase C (19-31)](https://file.medchemexpress.com/product_pic/hy-p1088.gif "Click to View [Ser25] Protein Kinase C (19-31) Product Detail")
0 ImagesCat. No.: HY-P1088CAS No.: 136795-05-6
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Prkcb Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11121Prkcb Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protein kinase inhibitor 7
0 ImagesCat. No.: HY-155619CAS No.: 84478-11-5Protein kinase inhibitor 7 is an inhibitor for protein kinase A and protein kinase C. Protein kinase inhibitor 7 affects autocrine motility factor (AMF) signaling pathway, without affecting the cell motility.
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Senkyunolide B
0 ImagesCat. No.: HY-W782599CAS No.: 93236-67-0Senkyunolide B is a phthalide found in Angelica sinensis. Senkyunolide B has broad antifungal activities. Senkyunolide B affects the spore germination and hyphae growth of Aspergillus fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis and the expression of ENG genes.
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Mitoxantrone-d8
0 ImagesCat. No.: HY-13502SCAS No.: 1189974-82-0Synonyms: Mitozantrone-d8; NSC 301739-d8Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
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Prkcg Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11129Prkcg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Prkcg Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS11130Prkcg Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
0 ImagesCat. No.: HY-N12466CAS No.: 2226941-29-13′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM.
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Daphnetin (Standard)
0 ImagesDaphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.
