1189974-82-0
1189974-82-0
Chemical Structure
Mitoxantrone-d8
Synonym(s): Mitozantrone-d8;NSC 301739-d8
- CAS No.: 1189974-82-0
- Formula:C22H20D8N4O6
- Molecular Weight:452.53
IUPAC Name: 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl-1,1,2,2-d4)amino)ethyl)amino)anthracene-9,10-dione
InChIKey: KKZJGLLVHKMTCM-PMCMNDOISA-N
SMILES: N(CCNC(C(O)([2H])[2H])([2H])[2H])C1=C2C(=C(NCCNC(C(O)([2H])[2H])([2H])[2H])C=C1)C(=O)C=3C(C2=O)=C(O)C=CC3O
Biological Activity: Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
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Mitoxantrone-d8 | Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | |||||||||||||||||||||
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Mitoxantrone (Standard) | ≥98% | Mitoxantrone (Standard) is the analytical standard of Mitoxantrone. This product is intended for research and analytical applications. Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively. | ||||||||||||||||||||
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Mitoxantrone | 99.58% | Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. [Content Brief]
