2226941-29-1
2226941-29-1
Chemical Structure
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
- CAS No.: 2226941-29-1
- Formula:C28H24N4O4
- Molecular Weight:480.51
InChIKey: PTQKRCXNRU-LCWSOADTSA-N
SMILES: O=C1C2=C3C(N4C5=C3C=CC=C5)=C6C(C(C=CC=C7)=C7N6[C@]8(C)[C@H](O)[C@@H](NC(C)=O)C[C@@]4([H])O8)=C2CN1
Biological Activity: 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM[1].
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3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine | 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM. | |||||||||||||||||||||
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References
