PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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PROTAC Linkers Verwandte Produkte (4114)
Verwandte Produkte (4114)
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PROTAC Linkers Isoform Comparison
![7-(Tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w021171.gif "Click to View 7-(Tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid Product Detail")
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8-Bromooctan-1-ol
0 ImagesSynonyms: 8-Bromo-1-octanol
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3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid
0 ImagesArt. -Nr.: HY-W001452CAS. Nr.: 154775-43-6
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1,1-Dimethylethyl 4-(3-azetidinylmethyl)-1-piperazinecarboxylate
0 ImagesArt. -Nr.: HY-W587186CAS. Nr.: 1780637-40-2
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tert-Butyl (8-bromooctyl)carbamate
0 ImagesArt. -Nr.: HY-23016CAS. Nr.: 142356-35-2
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tert-Butyl 9-bromononanoate
0 ImagesArt. -Nr.: HY-W096874CAS. Nr.: 135982-11-5
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Propargyl-PEG2-acid
0 ImagesPropargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Azetidin-3-ol hydrochloride
0 ImagesAzetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.
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N-Boc-4-pentyne-1-amine
0 ImagesArt. -Nr.: HY-43721CAS. Nr.: 151978-50-6N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122). N-Boc-4-pentyne-1-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Bromo-PEG5-Boc
0 ImagesArt. -Nr.: HY-141366CAS. Nr.: 1415800-38-2
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N-DBCO-N-bis(PEG2-C2-NHS ester)
0 ImagesArt. -Nr.: HY-140585CAS. Nr.: 2128735-29-3N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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Mal-PEG2-acid
0 ImagesMal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.
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Mal-PEG24-NHS ester
0 ImagesArt. -Nr.: HY-135819CAS. Nr.: 2226733-37-3
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Propargyl-PEG4-acid
0 ImagesArt. -Nr.: HY-130481CAS. Nr.: 1415800-32-6Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Biotin-PEG3-SH
0 ImagesArt. -Nr.: HY-132115CAS. Nr.: 1244028-52-1
