1. Apoptosis
  2. Apoptosis
  3. MG-277

MG-277 

Cat. No.: HY-130122
Handling Instructions

MG-277 works as a molecular glue molecule that is converted from a bona fide MDM2 proteolysis targeting chimeras (PROTAC) degrader by simple structural modifications, can induce degradation of a translation termination factor, GSPT1 to achieve its potent anticancer activity.

For research use only. We do not sell to patients.

MG-277 Chemical Structure

MG-277 Chemical Structure

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Description

MG-277 works as a molecular glue molecule that is converted from a bona fide MDM2 proteolysis targeting chimeras (PROTAC) degrader by simple structural modifications, can induce degradation of a translation termination factor, GSPT1 to achieve its potent anticancer activity[1].

Molecular Weight

774.71

Formula

C₄₁H₄₂Cl₂FN₅O₅

SMILES

ClC1=CC=C2C(NC([[email protected]@]23C4(N[[email protected]]([[email protected]@H]3C5=CC=CC(Cl)=C5F)C(NCCCCCC6=C(C7=CC=C6)CN(C7=O)C8C(NC(CC8)=O)=O)=O)CCCCC4)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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KeyWords:

MG-277 | MG277 | MG 277 | Apoptosis | Inhibitor | inhibitor | inhibit

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MG-277
Cat. No.:
HY-130122
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