N-DBCO-N-bis(PEG2-C2-NHS ester)
Based on 1 Customer Validation
N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 95.01%
- CAS No.: 2128735-29-3
- Formula: C41H46N4O14
- Molecular Weight:818.82
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2128735-29-3
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Appearance Solid
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Molecular Weight 818.82
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Formula C41H46N4O14
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Color Light yellow to brown
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SMILES
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(ON(C4=O)C(CC4)=O)=O)CCOCCOCCC(ON(C5=O)C(CC5)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 50 mg/mL (61.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2213 mL | 6.1063 mL | 12.2127 mL | 30.5317 mL |
| 5 mM | 0.2443 mL | 1.2213 mL | 2.4425 mL | 6.1063 mL | |
| 10 mM | 0.1221 mL | 0.6106 mL | 1.2213 mL | 3.0532 mL | |
| 15 mM | 0.0814 mL | 0.4071 mL | 0.8142 mL | 2.0354 mL | |
| 20 mM | 0.0611 mL | 0.3053 mL | 0.6106 mL | 1.5266 mL | |
| 25 mM | 0.0489 mL | 0.2443 mL | 0.4885 mL | 1.2213 mL | |
| 30 mM | 0.0407 mL | 0.2035 mL | 0.4071 mL | 1.0177 mL | |
| 40 mM | 0.0305 mL | 0.1527 mL | 0.3053 mL | 0.7633 mL | |
| 50 mM | 0.0244 mL | 0.1221 mL | 0.2443 mL | 0.6106 mL | |
| 60 mM | 0.0204 mL | 0.1018 mL | 0.2035 mL | 0.5089 mL |
N-DBCO-N-bis(PEG2-C2-NHS ester) Related Classifications
HY-140585 Related Classifications
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