N-DBCO-N-bis(PEG2-C2-acid)
Based on 1 Customer Validation
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2110449-00-6
- Formula: C33H40N2O10
- Molecular Weight:624.68
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2110449-00-6
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Appearance Liquid (Density: 1.32 g/cm3)
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Molecular Weight 624.68
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Formula C33H40N2O10
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Color Light yellow to yellow
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SMILES
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(O)=O)CCOCCOCCC(O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (200.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6008 mL | 8.0041 mL | 16.0082 mL | 40.0205 mL |
| 5 mM | 0.3202 mL | 1.6008 mL | 3.2016 mL | 8.0041 mL | |
| 10 mM | 0.1601 mL | 0.8004 mL | 1.6008 mL | 4.0020 mL | |
| 15 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6680 mL | |
| 20 mM | 0.0800 mL | 0.4002 mL | 0.8004 mL | 2.0010 mL | |
| 25 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 30 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 40 mM | 0.0400 mL | 0.2001 mL | 0.4002 mL | 1.0005 mL | |
| 50 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8004 mL | |
| 60 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL | |
| 80 mM | 0.0200 mL | 0.1001 mL | 0.2001 mL | 0.5003 mL | |
| 100 mM | 0.0160 mL | 0.0800 mL | 0.1601 mL | 0.4002 mL |
N-DBCO-N-bis(PEG2-C2-acid) Related Classifications
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