Propargyl-PEG4-acid

Name: Propargyl-PEG4-acid
Brand: MedChemExpress
SKU: HY-130481
Rating: 4.5 (1 reviews)

Cat. No.: HY-130481 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC₅₀ of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG4-acid Chemical Structure

CAS No. : 1415800-32-6

Size	Price	Stock	Quantity
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 43	In-stock	Estimated Time of Arrival: December 31
5 g	USD 190	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC₅₀ of 200 nM in THP-1 cells^[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

BTK-IAP PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of IAP E3 ligases family recruitment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.28

Formula

C₁₂H₂₀O₆

CAS No.

1415800-32-6

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (192.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8420 mL	19.2101 mL	38.4202 mL
5 mM	0.7684 mL	3.8420 mL	7.6840 mL
10 mM	0.3842 mL	1.9210 mL	3.8420 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (266 KB) SDS (0 KB)

COA (240 KB) HNMR (118 KB)

Handling Instructions (2659 KB)

References

[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8420 mL	19.2101 mL	38.4202 mL	96.0504 mL
	5 mM	0.7684 mL	3.8420 mL	7.6840 mL	19.2101 mL
	10 mM	0.3842 mL	1.9210 mL	3.8420 mL	9.6050 mL
	15 mM	0.2561 mL	1.2807 mL	2.5613 mL	6.4034 mL
	20 mM	0.1921 mL	0.9605 mL	1.9210 mL	4.8025 mL
	25 mM	0.1537 mL	0.7684 mL	1.5368 mL	3.8420 mL
	30 mM	0.1281 mL	0.6403 mL	1.2807 mL	3.2017 mL
	40 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4013 mL
	50 mM	0.0768 mL	0.3842 mL	0.7684 mL	1.9210 mL
	60 mM	0.0640 mL	0.3202 mL	0.6403 mL	1.6008 mL
	80 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2006 mL
	100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9605 mL