1415800-32-6
Chemical Structure
Propargyl-PEG4-acid
- CAS No.: 1415800-32-6
- Formula:C12H20O6
- Molecular Weight:260.28
IUPAC Name: 4,7,10,13-tetraoxahexadec-15-ynoic acid
InChIKey: WMBXAUWIPBFEOK-UHFFFAOYSA-N
SMILES: C#CCOCCOCCOCCOCCC(O)=O
Biological Activity: Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Propargyl-PEG4-acid | 97.0% | Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Keywords
