1. Neuronal Signaling
  2. Amyloid-β
  3. Aβ/tau aggregation-IN-1

Aβ/tau aggregation-IN-1 

Cat. No.: HY-141661
Handling Instructions

Aβ/tau aggregation-IN-1 is a potent 1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier.

For research use only. We do not sell to patients.

Aβ/tau aggregation-IN-1 Chemical Structure

Aβ/tau aggregation-IN-1 Chemical Structure

CAS No. : 2252162-81-3

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Description

Aβ/tau aggregation-IN-1 is a potent 1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier[1].

IC50 & Target

Kd: 160 μM (Aβ1-42)[1].
Kd: 337 μM (tau)[1]

In Vitro

Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci[1].
Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ1-42 and tau. The KD value of Aβ/tau aggregation-IN-1 with Aβ1-42 is 160 μM. The KD value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ1-42 and tau through noncovalent interactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[1]

Cell Line: HEK-293 T cells
Concentration: 1 μM
Incubation Time: 24 hours
Result: Significantly declined the tau aggregation foci.
Molecular Weight

492.35

Formula

C₂₅H₂₁IN₂O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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Aβ/tau aggregation-IN-1
Cat. No.:
HY-141661
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