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Art. -Nr.: HY-N16714

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Clausine K

Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods.

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CAS. Nr.: 182261-96-7
Formel: C₁₅H₁₃NO₄
Molecular Weight:271.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Clausine K Chemical Structure

CAS. Nr.: 182261-96-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	4.6 μM Compound: 55	Inhibition of NO production in LPS-stimulated mouse BV-2 cells preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse BV-2 cells preincubated with compound for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay	[PMID: 33454546]

Chemical Information

CAS. Nr. 182261-96-7
Molecular Weight 271.27
Formel C₁₅H₁₃NO₄
SMILES

O=C(C1=C(OC)C=C(NC2=C3C=CC(OC)=C2)C3=C1)O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chakthong S, et al. Carbazole-pyranocoumarin conjugate and two carbazole alkaloids from the stems of Clausena excavata. Nat Prod Res. 2016 Aug;30(15):1690-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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