LY 178210
LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061). LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations.
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- CAS. Nr.: 114943-19-0
- Formel: C18H25N3O
- Molecular Weight:299.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
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5-HT1A Receptor 0.67 nM (IC50) |
5-HT1D Receptor 380 nM (IC50) |
Chemical Information
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CAS. Nr. 114943-19-0
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Molecular Weight 299.41
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Formel C18H25N3O
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SMILES
O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Flaugh ME, et al. 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists. J Med Chem. 1988 Sep;31(9):1746-53. [Content Brief]
[2]. Slaughter JL, et al. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990;47(15):1331-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LY 178210 Related Classifications
HY-129481 Related Classifications
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