(R)-PVTX-405
(R)-PVTX-405 is a IKZF2 molecular glue degrader with a DC50 of 4.1 nM. (R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930). PVTX-405 is an orally active IKZF2 molecular glue degrader that significantly inhibits MC38 tumor growth in mouse tumor xenograft models. (R)-PVTX-405 can be used in cancer-related research.
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- CAS. Nr.: 2991023-13-1
- Formel: C30H31N5O4
- Molecular Weight:525.60
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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IKZF2 4.1 nM (DC50) |
(R)-PVTX-405 (0.017 nM-10 μM; 6 h) induces IKZF2 degradation in HEK293 IKZF2 HiBiT cells, with a DC50 of 4.1 nM and a maximum degradation rate of 89%[1].
(R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930) (compound 16a). PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a Dmax of 91%. PVTX-405 improves degradation efficiency, significantly reduces off-target degradation, and attenuates hERG inhibition with an IC50 of 48 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2991023-13-1
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Appearance Solid
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Molecular Weight 525.60
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Formel C30H31N5O4
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SMILES
O=C1N(CC2=C1C=CC3=C2OCC34CCN(CC5=CC=CC(C(C=N6)=CN6C)=C5)CC4)[C@@H](C7=O)CCC(N7)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(R)-PVTX-405 Related Classifications
HY-172930B Related Classifications
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