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Art. -Nr.: HY-101384

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Ro 10-5824

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Ro 10-5824 is a potent and selective D4R partial agonist with a K_i of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice.

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CAS. Nr.: 189744-46-5
Formel: C₁₇H₂₀N₄
Molecular Weight:280.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Ro 10-5824 Chemical Structure

CAS. Nr.: 189744-46-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Publications (2)
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Beschreibung

Ro 10-5824 is a potent and selective D4R partial agonist with a K_i of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice^[1]^[2].

IC₅₀ & Target

Dopamine D4 receptor

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 189744-46-5
Molecular Weight 280.38
Formel C₁₇H₂₀N₄
SMILES

N=1C=C(C(=NC1C)N)CN2CC=C(C=3C=CC=CC3)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Br J Pharmacol

Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]

2026 Aug;183(15):4178-4195. PMID: 42025290
Brain Behav Immun

Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. [Abstract]

2020 Oct;89:133-144. PMID: 32505714

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81. [Content Brief]

[2]. Cummings DF, et al. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. J Pharmacol Exp Ther. 2010 Jun;333(3):682-95. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ro 10-5824

2 Cited Publications

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Ro 10-5824

Publications Citing Use of MedChemExpress (MCE) Ro 10-5824

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Ro 10-5824 Related Classifications

HY-101384 Related Classifications