Ro 10-5824 dihydrochloride
Based on 2 publication(s) in Google Scholar
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 189744-94-3
- Formula: C17H22Cl2N4
- Molecular Weight:353.29
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ro 10-5824 dihydrochloride
MoreAll Dopamine Receptor Isoforms
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Biological Activity
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D4 Receptor |
RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 189744-94-3
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Appearance Solid
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Molecular Weight 353.29
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Formula C17H22Cl2N4
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Color White to off-white
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SMILES
NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]2026 Aug;183(15):4178-4195. PMID: 42025290 -
Brain Behav Immun
Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. [Abstract]2020 Oct:89:133-144. PMID: 32505714
Solvent & Solubility
H2O : 100 mg/mL (283.05 mM; Need ultrasonic)
DMSO : 8.33 mg/mL (23.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (141.53 mM); Clear solution; Need ultrasonic
Protocol
In the experiment, 39 C57 and 40 DBA mice are tested over a three-day period. On days 1 and 2, mice are placed into the VT for 60 min and locomotor behavior is recorded. On the third day, mice are placed into the VT chamber for 60 min. Following the 60-min period, mice are removed from the chambers and administered 0, 1.0, 3.0, or 10.0 mg/kg of RO-10-5824 (n=9-11 per group). Mice are assigned to drug group pseudo-randomly, with each dose being represented in a cage of four mice. A novel paper cup measuring 9.5 cm in height and 7.5 cm in diameter at the rim is placed upside down in the center of each open field and secured to the floor with tape. Mice are returned to the VT 10 min following injection and tested for an additional 30 min.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl). 2015 Sep;232(17):3287-95. [Content Brief]
[2]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.8305 mL | 14.1527 mL | 28.3054 mL | 70.7634 mL |
| 5 mM | 0.5661 mL | 2.8305 mL | 5.6611 mL | 14.1527 mL | |
| 10 mM | 0.2831 mL | 1.4153 mL | 2.8305 mL | 7.0763 mL | |
| 15 mM | 0.1887 mL | 0.9435 mL | 1.8870 mL | 4.7176 mL | |
| 20 mM | 0.1415 mL | 0.7076 mL | 1.4153 mL | 3.5382 mL | |
| H2O | 25 mM | 0.1132 mL | 0.5661 mL | 1.1322 mL | 2.8305 mL |
| 30 mM | 0.0944 mL | 0.4718 mL | 0.9435 mL | 2.3588 mL | |
| 40 mM | 0.0708 mL | 0.3538 mL | 0.7076 mL | 1.7691 mL | |
| 50 mM | 0.0566 mL | 0.2831 mL | 0.5661 mL | 1.4153 mL | |
| 60 mM | 0.0472 mL | 0.2359 mL | 0.4718 mL | 1.1794 mL | |
| 80 mM | 0.0354 mL | 0.1769 mL | 0.3538 mL | 0.8845 mL | |
| 100 mM | 0.0283 mL | 0.1415 mL | 0.2831 mL | 0.7076 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ro 10-5824 dihydrochloride Related Classifications
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