1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Ro 10-5824 dihydrochloride

Ro 10-5824 dihydrochloride 

Cat. No.: HY-101384A Purity: 99.93%
Handling Instructions

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

For research use only. We do not sell to patients.

Ro 10-5824 dihydrochloride Chemical Structure

Ro 10-5824 dihydrochloride Chemical Structure

CAS No. : 189744-94-3

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Based on 1 publication(s) in Google Scholar

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Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

IC50 & Target

Ki: 5.2 nM (dopamine D4 receptor)[2]

In Vitro

RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level[2].

In Vivo

Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion[1]. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (283.05 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (23.58 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8305 mL 14.1527 mL 28.3054 mL
5 mM 0.5661 mL 2.8305 mL 5.6611 mL
10 mM 0.2831 mL 1.4153 mL 2.8305 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

In the experiment, 39 C57 and 40 DBA mice are tested over a three-day period. On days 1 and 2, mice are placed into the VT for 60 min and locomotor behavior is recorded. On the third day, mice are placed into the VT chamber for 60 min. Following the 60-min period, mice are removed from the chambers and administered 0, 1.0, 3.0, or 10.0 mg/kg of RO-10-5824 (n=9-11 per group). Mice are assigned to drug group pseudo-randomly, with each dose being represented in a cage of four mice. A novel paper cup measuring 9.5 cm in height and 7.5 cm in diameter at the rim is placed upside down in the center of each open field and secured to the floor with tape. Mice are returned to the VT 10 min following injection and tested for an additional 30 min.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Ro 10-5824Dopamine ReceptorInhibitorinhibitorinhibit

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