189744-46-5
189744-46-5
Chemical Structure
Ro 10-5824
- CAS No.: 189744-46-5
- Formula:C17H20N4
- Molecular Weight:280.38
IUPAC Name: 2-methyl-5-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine
InChIKey: KABDATZAOUSYES-UHFFFAOYSA-N
SMILES: N=1C=C(C(=NC1C)N)CN2CC=C(C=3C=CC=CC3)CC2
Biological Activity: Ro 10-5824 is a potent and selective D4R partial agonist with a Ki of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice[1][2].
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Ro 10-5824 | Ro 10-5824 is a potent and selective D4R partial agonist with a Ki of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice. | |||||||||||||||||||||
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References
- [1]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81. [Content Brief]
- [2]. Cummings DF, et al. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. J Pharmacol Exp Ther. 2010 Jun;333(3):682-95. [Content Brief]
