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Art. -Nr.: HY-180995

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VARS1-IN-1

VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a K_d of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer.

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CAS. Nr.: 428830-84-6
Formel: C₂₁H₁₅N₅OS
Molecular Weight:385.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

VARS1-IN-1 Chemical Structure

CAS. Nr.: 428830-84-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

VARS1-IN-1 (Compound 2701) (10 µM; 2 days) interfers VARS1’s tRNA aminoacylation activity but not its expression with a reduction in charged to total tRNA-Val ratio in prostate cancer cells^[1].
VARS1-IN-1 (10 µM; 2 days) redues total protein synthesis rate in PC3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VARS1-IN-1 (Compound 2701) (15 mg/kg; i.p.; once every other day for 20 days) suppresses tumor growth and cell proliferation in male BALB/c-nu nude mice PC3 prostate cancer xenograft^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c-nu nude mice with PC3 xenograft (male, 6-7 weeks old)^[1]
Dosage:

15 mg/kg
Administration:

i.p.; once every other day for 20 days
Result:

Inhibited tumor growth with significant reduction in tumor weight compared to DMSO control.
Decreased cell proliferation index as shown by Ki-67 immunohistochemical staining.

Chemical Information

CAS. Nr. 428830-84-6
Molecular Weight 385.44
Formel C₂₁H₁₅N₅OS
SMILES

CC1=CC=C(C2=NN(C(/C3=C/C4=CNC5=C4C=CC=C5)=N)C(S2)=NC3=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. He Q, et al. VARS1 fuels prostate cancer evolution via codon-selective translational rewiring[J]. bioRxiv, 2025: 2025.12. 09.693333.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
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VARS1-IN-1

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

VARS1-IN-1 Related Classifications

HY-180995 Related Classifications