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Cat. No.: HY-183001

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ATX-012

ATX-012 is an ionizable cationic lipid for the assembly of mRNA-delivering lipid nanoparticles (LNPs). ATX-012 blends with helper lipids, cholesterol and PEG-lipid conjugates to form mRNA-containing nanocarriers, which support efficient cellular internalization and the generation of functional proteins including CFTR. ATX-012 constitutes the vital building block of LNPs applied in cystic fibrosis-related biological studies.

For research use only. We do not sell to patients.

CAS No.: 1777792-44-5
Formula: C₄₂H₇₈N₂O₅S
Molecular Weight:723.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ATX-012 Chemical Structure

CAS No.: 1777792-44-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

ATX-012 can form LNPs featuring high mRNA encapsulation efficiency (> 95%) and a small particle size ranging from 70 to 90 nm, and such LNPs achieve efficient mRNA delivery into lung epithelial cells in vitro and in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATX-012 (intratracheal administration)-formulated LNPs deliver mRNA to mouse lung epithelial cells and drive protein expression throughout large and small airways^[1].
ATX-012 (1 mg/kg; intranasal administration; once daily for two days)-based LNPs loaded with hCFTR mRNA restore functional chloride channel activity in CFTR knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CFTR knockout mice^[1]
Dosage:

1 mg/kg
Administration:

intranasal administration; once daily for two days
Result:

Restored functional chloride channel activity when loaded with hCFTR mRNA.

Chemical Information

CAS No. 1777792-44-5
Molecular Weight 723.14
Formula C₄₂H₇₈N₂O₅S
SMILES

CCN(CCCSC(N(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carlos G, et al. Lipid formulations containing nucleic acids and methods of treatment for cystic fibrosis. US20230159449A1. United States. 2022-11-03.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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