1777792-44-5
Chemical Structure
ATX-012
- CAS No.: 1777792-44-5
- Formula:C42H78N2O5S
- Molecular Weight:723.14
IUPAC Name: di((Z)-non-2-en-1-yl) 8,8'-((((3-(diethylamino)propyl)thio)carbonyl)azanediyl)dioctanoate
InChIKey: HCLBBIPTPLUJJQ-HONQWNAWSA-N
SMILES: CCN(CCCSC(N(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O)CC
Biological Activity: ATX-012 is an ionizable cationic lipid for the assembly of mRNA-delivering lipid nanoparticles (LNPs). ATX-012 blends with helper lipids, cholesterol and PEG-lipid conjugates to form mRNA-containing nanocarriers, which support efficient cellular internalization and the generation of functional proteins including CFTR. ATX-012 constitutes the vital building block of LNPs applied in cystic fibrosis-related biological studies[1].
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ATX-012 | ATX-012 is an ionizable cationic lipid for the assembly of mRNA-delivering lipid nanoparticles (LNPs). ATX-012 blends with helper lipids, cholesterol and PEG-lipid conjugates to form mRNA-containing nanocarriers, which support efficient cellular internalization and the generation of functional proteins including CFTR. ATX-012 constitutes the vital building block of LNPs applied in cystic fibrosis-related biological studies. | |||||||||||||||||||||
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Keywords
