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Cat. No.: HY-101373

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Zolantidine

(Synonyms: SK&F 95282)

Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception.

For research use only. We do not sell to patients.

CAS No.: 104076-38-2
Formula: C₂₂H₂₇N₃OS
Molecular Weight:381.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Zolantidine Chemical Structure

CAS No.: 104076-38-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception^[1]^[2].

IC₅₀ & Target^[1]

H₂ Receptor

All Histamine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	76 μM Compound: Zolantidine	Cytotoxicity activity against human HepG2 cells after 24 hrs Cytotoxicity activity against human HepG2 cells after 24 hrs	[PMID: 20547797]

In Vivo

Zolantidine (5, 10, 20, 40 mg/kg; s.c.) induces antinociception in cholestatic rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

200-250 g, male Wistar rats (cholestatic rats)^[2]
Dosage:

5, 10, 20, 40 mg/kg
Administration:

S.c.
Result:

Significantly increased tail-flick latencies and induced antinociception.

Chemical Information

CAS No. 104076-38-2
Molecular Weight 381.53
Formula C₂₂H₂₇N₃OS
SMILES

C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
Synonyms

SK&F 95282
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [Content Brief]

[2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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Zolantidine

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Zolantidine Related Classifications

HY-101373 Related Classifications