AT1R-agonist-1

AT1R-agonist-1 (Compound 12) (10 μM; 10 min) acts as a highly weak partial agonist of Gαq signaling in AT1R-expressing HEK293 cells, with an EC₅₀ > 10,000 nM and 11% relative efficacy to AngII^[1].
AT1R-agonist-1 (dose-response concentrations, 10 μM; 10 min) potently recruits β-arrestin2 to AT1R in HEK293 cells, with an EC₅₀ of 2.5 nM and 89% relative efficacy to AngII^[1].
AT1R-agonist-1 (dose-response concentrations, 10 μM; 10 min) acts as a partial agonist of PKC signaling in AT1R-expressing HEK293 cells, with an EC₅₀ of 4.8 nM and 51% relative efficacy to AngII^[1].
AT1R-agonist-1 (dose-response concentrations, 10 μM; 3 min) acts as a partial agonist of Rho signaling in Gα₁₂/₁₃-knockout, AT1R-expressing HEK293 cells, with an EC₅₀ of 21 nM and 47% relative efficacy to AngII^[1].
AT1R-agonist-1 (10 μM; 1 min) shows negligible PKC activation in rat primary VSMCs, with an EC₅₀ >10,000 nM and 13% relative efficacy to AngII^[1].
AT1R-agonist-1 (10 μM; 1 min 30 s) shows negligible Rho activation in rat primary VSMCs, with an EC₅₀ >10,000 nM and 12% relative efficacy to AngII^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.