3124030-35-6
Chemical Structure
AT1R-agonist-1
- CAS No.: 3124030-35-6
- Formula:C57H77N13O13
- Molecular Weight:1152.30
InChIKey: NCTYRWLFRFMYFL-OSCGAACLSA-N
SMILES: O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC2=CC=C(OCC3=CC=CC=C3)C=C2)=O)CCC1)=O)CC4=CNC=N4)=O)[C@H](CC)C)=O)CC5=CC=C(O)C=C5)=O)C(C)C)=O)CCCNC(N)=N
Biological Activity: AT1R-agonist-1 is an angiotensin II type 1 receptor (AT1R) agonist with a Ki value of 1.4 nM. AT1R-agonist-1 exhibits low Gαq activity, retains β-arrestin recruitment function, and accesses the deep allosteric pocket inside AT1R via its flexible side chain. AT1R-agonist-1 possesses positive inotropic effects (enhancing cardiac contractile function) and causes almost no increase in blood pressure. AT1R-agonist-1 can be used for research on conditions such as refractory cardiogenic shock[1].
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AT1R-agonist-1 | AT1R-agonist-1 is an angiotensin II type 1 receptor (AT1R) agonist with a Ki value of 1.4 nM. AT1R-agonist-1 exhibits low Gαq activity, retains β-arrestin recruitment function, and accesses the deep allosteric pocket inside AT1R via its flexible side chain. AT1R-agonist-1 possesses positive inotropic effects (enhancing cardiac contractile function) and causes almost no increase in blood pressure. AT1R-agonist-1 can be used for research on conditions such as refractory cardiogenic shock. | |||||||||||||||||||||
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Keywords
