2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis RSV
  4. AVG-233

AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC50=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV).

For research use only. We do not sell to patients.

AVG-233 Chemical Structure

AVG-233 Chemical Structure

CAS No. : 2151937-80-1

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Based on 1 publication(s) in Google Scholar

AVG-233 Related Antibodies

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  • Purity & Documentation

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Description

AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC50=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV)[1][2].

In Vitro

AVG-233 (1-100 μM) blocks 3´RNA extension elongation but does not interfere with 3´RNA extension by up to three nucleotides after de novo initiation from the promoter or back-priming[1].
AVG-233 (20 μM) reduces virus yield of RSV A2-L19F (EC50=0.31 μM), RSV strain 2-20 (EC50=0.14 μM) and RSV clinical isolate 718 (EC50=0.2 μM) [1].
AVG-233 (1.25-40 μM; 0-300 s) suppresses RNA synthesis by the L1-1749 fragment in a dose-dependent manner with an IC50 value of 13.7 μM. AVG-233 bounds L and the L1-1749 fragment with similar affinities (dissociation constants (KD’s) are 38.3 μM and 53.1 μM, respectively)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AVG-233 Related Antibodies
In Vivo

AVG-233 (50-100 mg/kg; i.g.; once) decreases lung viral load in the RSV mouse model[2].
AVG-233 (2-20 mg/kg; i.v. and p.o.; once; male CD-1 mice) has good orally bioavailable and the maximum plasma concentration about 2 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/cJ mice with recRSV-mKate xenograft[2]
Dosage: 50 and 100 mg/kg
Administration: Oral gavage; once
Result: Reduced in lung viral load of 0.89 log10 TCID50 (median tissue culture infectious dose)/mL.
Animal Model: Male CD-1 mice (27-29 g)[1]
Dosage: 2 mg/kg (i.v.) and 20 mg/kg (p.o.)
Administration: Intravenous injection and oral administration; once, obtains blood samples at pre-dose and 0.083, 0.25, 0.5, 1, 2, 4, 8, and 24 h post-dosing
Result: 1.19
Route Dose Tmax Cmax AUC0-∞ CL/F T1/2 Bioavailability
mg/kg h nmol/ml h×nmol/ml liters/h/kg h %
Oral 20 1 2.17 5.95 6.98 5.28 33.8
Molecular Weight

487.94

Formula

C26H22ClN5O3
CAS No.
Appearance

Solid

SMILES

O=C1N(C2=NC=CC=C2)N(CC3=CC=C(OC)C=C3)C(C1=C(C)N4CC5=NC(Cl)=CC=C5)=CC4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0494 mL 10.2472 mL 20.4943 mL
5 mM 0.4099 mL 2.0494 mL 4.0989 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.87%

COA (254 KB) HNMR (274 KB) RP-HPLC (5054 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0494 mL 10.2472 mL 20.4943 mL 51.2358 mL
5 mM 0.4099 mL 2.0494 mL 4.0989 mL 10.2472 mL
10 mM 0.2049 mL 1.0247 mL 2.0494 mL 5.1236 mL
15 mM 0.1366 mL 0.6831 mL 1.3663 mL 3.4157 mL
20 mM 0.1025 mL 0.5124 mL 1.0247 mL 2.5618 mL
25 mM 0.0820 mL 0.4099 mL 0.8198 mL 2.0494 mL
30 mM 0.0683 mL 0.3416 mL 0.6831 mL 1.7079 mL
40 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.2809 mL
50 mM 0.0410 mL 0.2049 mL 0.4099 mL 1.0247 mL
60 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8539 mL
80 mM 0.0256 mL 0.1281 mL 0.2562 mL 0.6404 mL
100 mM 0.0205 mL 0.1025 mL 0.2049 mL 0.5124 mL
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AVG-233 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVG-2332151937-80-1AVG233AVG 233DNA/RNA SynthesisRSVRespiratory syncytial virusviral polymerase complexL1-1749RNARSV strainsrespiratory syncytial virusclinical RSV isolatesInhibitorinhibitorinhibit

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