Hyodeoxycholic acid sodium
Based on 6 publication(s) in Google Scholar
Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 10421-49-5
- Formula: C24H39NaO4
- Molecular Weight:414.55
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hyodeoxycholic acid sodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
- Redox Biol. 2026 May:92:104096. [Abstract]
- Cell Death Differ. 2026 Mar 11. [Abstract]
- Transl Psychiatry. 2025 Oct 6;15(1):366. [Abstract]
Customer Validation & Images
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WB
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RT-PCR
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IHC
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IF
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Hyodeoxycholic acid sodium is a secondary hydrophilic bile acid formed in the small intestine by the gut flora, and acts as an agonist of TGR5, with an EC50 of 31.6 μM in CHO cells[1].
Hyodeoxycholic acid (50, 100 μM) sodium increases the expression of genes (Abca1, Abcg1, and Apoe) involved in cholesterol efflux in RAW 264.7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 10421-49-5
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Appearance Solid
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Molecular Weight 414.55
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Formula C24H39NaO4
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Color White to off-white
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SMILES
C[C@@H]([C@H]1CC[C@]2([C@@]3(C[C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H])CCC(O[Na])=O
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Synonyms
HDCA sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
J Adv Res
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling. [Abstract]2025 Jul 11:S2090-1232(25)00543-0. PMID: 40653266
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Representative immunoblots treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
PWT and PWL of mice following Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.) treatment, relative expression levels of FXR mRNA.
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Immunohistochemical staining of FXR + cells and Alcian Blue staining in the distal ileum treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Immunofluorescence staining and mean fluorescence intensity of Mucin-2 treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
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Redox Biol
Hyodeoxycholic acid attenuates atherosclerosis by antagonizing FXR and modulating the PD-1/mTORC1 signaling axis. [Abstract]2026 May:92:104096. PMID: 41775219 -
Cell Death Differ
Gut-derived hyodeoxycholate reprograms the spleen-eye immunometabolic axis to suppress autoimmune uveitis. [Abstract]2026 Mar 11. PMID: 41813862 -
Transl Psychiatry
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus. [Abstract]2025 Oct 6;15(1):366. PMID: 41053031
Solvent & Solubility
H2O : 35 mg/mL (84.43 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41. [Content Brief]
[2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.4123 mL | 12.0613 mL | 24.1225 mL | 60.3064 mL |
| 5 mM | 0.4825 mL | 2.4123 mL | 4.8245 mL | 12.0613 mL | |
| 10 mM | 0.2412 mL | 1.2061 mL | 2.4123 mL | 6.0306 mL | |
| 15 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0204 mL | |
| 20 mM | 0.1206 mL | 0.6031 mL | 1.2061 mL | 3.0153 mL | |
| 25 mM | 0.0965 mL | 0.4825 mL | 0.9649 mL | 2.4123 mL | |
| 30 mM | 0.0804 mL | 0.4020 mL | 0.8041 mL | 2.0102 mL | |
| 40 mM | 0.0603 mL | 0.3015 mL | 0.6031 mL | 1.5077 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4825 mL | 1.2061 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0051 mL | |
| 80 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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