10421-49-5
10421-49-5
Chemical Structure
Hyodeoxycholic acid sodium
Synonym(s): HDCA sodium
- CAS No.: 10421-49-5
- Formula:C24H39NaO4
- Molecular Weight:414.55
IUPAC Name: sodium (R)-4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
InChIKey: DUYSCILLIVEITB-ADQIWYCWSA-M
SMILES: C[C@@H]([C@H]1CC[C@]2([C@@]3(C[C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H])CCC(O[Na])=O
Biological Activity: Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hyodeoxycholic acid sodium | 95.0% | Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells. | ||||||||||||||||||||
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References
- [1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41. [Content Brief]
- [2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17. [Content Brief]
