Hyodeoxycholic acid sodium
Based on 6 publication(s) in Google Scholar
Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells.
For research use only. We do not sell to patients.
- CAS No.: 10421-49-5
- Formula: C24H39NaO4
- Molecular Weight:414.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Hyodeoxycholic acid sodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2025 Aug 19:S1931-3128(25)00291-4. [Abstract]
- Cell Death Differ. 2026 Mar 11. [Abstract]
- J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
- Redox Biol. 2026 May:92:104096. [Abstract]
- Transl Psychiatry. 2025 Oct 6;15(1):366. [Abstract]
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Hyodeoxycholic acid sodium is a secondary hydrophilic bile acid formed in the small intestine by the gut flora, and acts as an agonist of TGR5, with an EC50 of 31.6 μM in CHO cells[1].
Hyodeoxycholic acid (50, 100 μM) sodium increases the expression of genes (Abca1, Abcg1, and Apoe) involved in cholesterol efflux in RAW 264.7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 10421-49-5
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Molecular Weight 414.55
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Formula C24H39NaO4
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SMILES
C[C@@H]([C@H]1CC[C@]2([C@@]3(C[C@@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)[H])[H])CCC(O[Na])=O
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Synonyms
HDCA sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
2025 Aug 19:S1931-3128(25)00291-4. PMID: 40848719 -
Cell Death Differ
Gut-derived hyodeoxycholate reprograms the spleen-eye immunometabolic axis to suppress autoimmune uveitis. [Abstract]2026 Mar 11. PMID: 41813862 -
J Adv Res
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling. [Abstract]2025 Jul 11:S2090-1232(25)00543-0. PMID: 40653266
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Representative immunoblots treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
PWT and PWL of mice following Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.) treatment, relative expression levels of FXR mRNA.
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Immunohistochemical staining of FXR + cells and Alcian Blue staining in the distal ileum treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
Hyodeoxycholic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jul 11:S2090-1232(25)00543-0. [Abstract]
Immunofluorescence staining and mean fluorescence intensity of Mucin-2 treated with Hyodeoxycholic acid (HDCA) (20 mg/kg, i.g.).
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Redox Biol
Hyodeoxycholic acid attenuates atherosclerosis by antagonizing FXR and modulating the PD-1/mTORC1 signaling axis. [Abstract]2026 May:92:104096. PMID: 41775219 -
Transl Psychiatry
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus. [Abstract]2025 Oct 6;15(1):366. PMID: 41053031
Purity & Documentation
References
[1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41. [Content Brief]
[2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hyodeoxycholic acid sodium Related Classifications
HY-N0169A Related Classifications
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