216 Results for "

DNA polymerase inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (216)

216 Results for "DNA polymerase inhibitor" in MCE Product Catalog:

160
Resveratrol
Resveratrol
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160 Publications Verification
Cat. No.: HY-16561
CAS No.: 501-36-0
Synonyms: trans-Resveratrol; SRT501
Category:  

Anti-aging Vitis vinifera cv. Zalema Plants Vitaceae Infection Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer

Target:  

DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2

Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
160
Resveratrol (Standard)
Resveratrol (Standard)
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160 Publications Verification
Cat. No.: HY-16561R
CAS No.: 501-36-0
Synonyms: trans-Resveratrol (Standard); SRT501 (Standard)
Category:  

Infection Functional Molecules Anti-aging Sunscreen Research of Health Products Cosmetic Research Plants Disease Research Fields Inflammation/Immunology Cancer

Target:  

Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2

Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
100
Cytarabine
Cytarabine
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100 Cited Publications
Cat. No.: HY-13605
CAS No.: 147-94-4
Purity:  99.98%
Synonyms: Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C
Category:  

Infection Natural Products Microorganisms Marine natural products Sponge Endogenous metabolite Disease Research Fields

Target:  

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus

Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
100
Cytarabine hydrochloride
Cytarabine hydrochloride
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100 Cited Publications
Cat. No.: HY-13605A
CAS No.: 69-74-9
Purity:  99.67%
Synonyms: Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride
Target:  

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy

Research Areas:  

Infection Cancer

Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
50
ART558
ART558
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50 Cited Publications
Cat. No.: HY-141520
CAS No.: 2603528-97-6
Purity:  99.75%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

ART558 is a potent, selective and allosteric DNA polymerase theta (Polθ) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer .
48
Ivermectin
Ivermectin
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48 Cited Publications
Cat. No.: HY-15310
CAS No.: 70288-86-7
Purity:  98.28%
Synonyms: MK-933; CD-5024; K-237
Category:  

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:  

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
22
Suramin sodium salt
Suramin sodium salt
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22 Cited Publications
Cat. No.: HY-B0879A
CAS No.: 129-46-4
Synonyms: Suramin hexasodium salt
Target:  

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:  

Infection Cardiovascular Disease Cancer

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .
20
Letermovir
Letermovir
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20 Cited Publications
Cat. No.: HY-15233
CAS No.: 917389-32-3
Purity:  99.96%
Synonyms: AIC246; MK-8228
Target:  

CMV

Research Areas:  

Infection Cancer

Letermovir (AIC246) is a potent inhibitor of CMV, which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
16
Floxuridine
Floxuridine
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16 Cited Publications
Cat. No.: HY-B0097
CAS No.: 50-91-9
Synonyms: 5-Fluorouracil 2'-deoxyriboside
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial CMV HSV Apoptosis

Research Areas:  

Infection Cancer

Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .
15
Aphidicolin
Aphidicolin
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15 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
Category:  

Microorganisms Terpenoids Diterpenoids Disease Research Fields Inflammation/Immunology

Target:  

DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus

Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .
15
BMH-21
BMH-21
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15 Cited Publications
Cat. No.: HY-12484
CAS No.: 896705-16-1
Purity:  99.25%
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .
15
Neobavaisoflavone
Neobavaisoflavone
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15 Cited Publications
Cat. No.: HY-N0720
CAS No.: 41060-15-5
Category:  

Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer Isoflavones

Target:  

Apoptosis DNA/RNA Synthesis

Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .
14
Cidofovir
Cidofovir
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14 Cited Publications
Cat. No.: HY-17438
CAS No.: 113852-37-2
Synonyms: GS 0504; HPMPC; (S)-HPMPC
Category:  

Infection Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite

Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
10
Idoxuridine
Idoxuridine
0 Images
10 Cited Publications
Cat. No.: HY-B0307
CAS No.: 54-42-2
Synonyms: 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
Target:  

DNA/RNA Synthesis Phosphatase Orthopoxvirus

Research Areas:  

Infection Cancer

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
10
IMT1B
IMT1B
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10 Cited Publications
Cat. No.: HY-137067
CAS No.: 2304621-06-3
Purity:  99.45%
Synonyms: LDC203974
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .
8
7-Aminoactinomycin D
7-Aminoactinomycin D
0 Images
8 Cited Publications
Cat. No.: HY-D1020
CAS No.: 7240-37-1
Synonyms: 7-AAD
7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .
8
Tubercidin
Tubercidin
0 Images
8 Cited Publications
Cat. No.: HY-100126
CAS No.: 69-33-0
Purity:  99.24%
Synonyms: 7-Deazaadenosine
Category:  

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:  

Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .
7
Rifabutin
Rifabutin
0 Images
7 Cited Publications
Cat. No.: HY-17025
CAS No.: 72559-06-9
Synonyms: Ansamycin; LM-427
Target:  

DNA/RNA Synthesis Bacterial Antibiotic

Research Areas:  

Infection

Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
7
Vidarabine monohydrate
Vidarabine monohydrate
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7 Cited Publications
Cat. No.: HY-N6666
CAS No.: 24356-66-9
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV

Research Areas:  

Infection

Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
7
Vidarabine
Vidarabine
0 Images
7 Cited Publications
Cat. No.: HY-B0277
CAS No.: 5536-17-4
Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
Category:  

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields

Target:  

Apoptosis Fungal Reactive Oxygen Species (ROS) EBV HSV Antibiotic DNA/RNA Synthesis Drug Metabolite

Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
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