7240-37-1
Chemical Structure
7-Aminoactinomycin D
Synonym(s): 7-AAD
- CAS No.: 7240-37-1
- Formula:C62H87N13O16
- Molecular Weight:1270.43
IUPAC Name: 2,7-diamino-N1,N9-bis((6S,9R,10S,13S,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1]oxa[4,7,10,13]tetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
InChIKey: YXHLJMWYDTXDHS-PLEOHDNVSA-N
SMILES: O=C(N[C@H](C(N1[C@@](C(N(C)CC(N(C)[C@@H](C(C)C)C(O[C@@H]2C)=O)=O)=O)([H])CCC1)=O)C(C)C)[C@H]2NC(C(C(C(OC3=C(C)C(N)=C4)=C5C)=NC3=C4C(N[C@@H]6C(N[C@H](C(N7[C@@](C(N(C)CC(N(C)[C@@H](C(C)C)C(O[C@@H]6C)=O)=O)=O)([H])CCC7)=O)C(C)C)=O)=O)=C(N)C5=O)=O
Biological Activity: 7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects[1][2][3].
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7-Aminoactinomycin D | 97.25% | 7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects. | ||||||||||||||||||||
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7-Aminoactinomycin D (solution) | 7-Aminoactinomycin D (solution) (7-AAD (solution)) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects. Solvent and concentration: DMSO: 1 mg/mL |
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References
- [1]. Wadkins RM, et al. Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA. Biochemistry. 1991 Oct 1;30(39):9469-78. [Content Brief]
- [2]. Nadine C L Zembruski, et al. 7-Aminoactinomycin D for apoptosis staining in flow cytometry. Anal Biochem. 2012 Oct 1;429(1):79-81. [Content Brief]
- [3]. Hanen Sellami, et al. Molecular detection of Chlamydia trachomatis and other sexually transmitted bacteria in semen of male partners of infertile couples in Tunisia: the effect on semen parameters and spermatozoa apoptosis markers. PLoS One. 2014 Jul 14;9(7):e98903. [Content Brief]
