5536-17-4
Chemical Structure
Vidarabine
Synonym(s): Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
- CAS No.: 5536-17-4
- Formula:C10H13N5O4
- Molecular Weight:267.25
IUPAC Name: (2R,3S,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: OIRDTQYFTABQOQ-UHTZMRCNSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1
Biological Activity: Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Vidarabine | 98.85% | Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis. | ||||||||||||||||||||
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Vidarabine (Standard) | ≥98% | Vidarabine (Ara-A) (Standard) is the analytical standard of Vidarabine. This product is intended for research and analytical applications. Vidarabine is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis. | ||||||||||||||||||||
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- [1]. Kimura H, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001;23(5):294-299. [Content Brief]
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[2]. Gough AW, et al. Comparison of the neonatal toxicity of two antiviral agents: Vidarabine phosphate and cytarabine. Toxicology and applied pharmacology. 1982 Oct 1;66(1):143-52.
- [3]. Gavandi TC, et al. Vidarabine as a novel antifungal agent against Candida albicans: insights on mechanism of action. Int Microbiol. 2025;28(3):589-602. [Content Brief]
Keywords
