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Cat. No.: HY-101744

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Ipsalazide

Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

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CAS No.: 82101-17-5
Formule: C₁₆H₁₁N₃Na₂O₆
Masse moléculaire:387.25

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Ipsalazide Chemical Structure

CAS No.: 82101-17-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Protocole
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

In Vitro

Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects. Ipsalazide is designed which the sulfapyridine of sulfasalazine has been replaced by carrier molecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

No deaths or visible abnormalities occurrs within 7 days of a single oral dose of ipsalazide (4 g/kg in mice or 2 g/kg in rats). No abnormalities were seen at postmortem. The ipsalazide carrier molecule (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, around 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, with loss of the aromatic amine function which is the basis for the colorimetric measurement of ABG^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 82101-17-5
Masse moléculaire 387.25
Formule C₁₆H₁₁N₃Na₂O₆
SMILES

O=C([O-])C1=CC(/N=N/C2=CC=C(C(NCC([O-])=O)=O)C=C2)=CC=C1O.[Na+].[Na+]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

Animal Administration^[1]

Rats^[1]
Maximum single doses administered orally are 2 g/kg body weight to 10 male and 10 female Biorex Wistar rats and 4 g/kg to 10 male and 10 female Swiss albino mice. The animals are observed for 7 days, any mortalities are recorded, and a full postmortem performed.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chan RP, et al. Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. Dig Dis Sci. 1983 Jul;28(7):609-15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- Description
- In Vitro
- In Vivo
Chemical Information
Protocole
Pureté et documentation
Références

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Ipsalazide

SBI-0206965

EN6

SMER28

QX77

Autophinib

STF-62247

ROC-325

PHY34

SMER28 (Standard)

Autophinib (Standard)

ROC-325 (Standard)

Lys01

Activité biologique

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

Ipsalazide

SBI-0206965

EN6

SMER28

QX77

Autophinib

STF-62247

ROC-325

PHY34

SMER28 (Standard)

Autophinib (Standard)

ROC-325 (Standard)

Lys01

Activité biologique

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

Help & FAQs

Ipsalazide Related Classifications

HY-101744 Related Classifications

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