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Aprutumab

(Synonyms: BAY 1179470)
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Aprutumab (BAY 1179470) is a fully human fibroblast growth factor receptor 2 (FGFR2)-specific monoclonal antibody. Aprutumab induces FGFR2 endocytosis and degradation in cancer cells expressing FGFR2. Aprutumab serves as the targeted monoclonal antibody component of the antibody-drug conjugate BAY 1187982 (HY-141600) and mediates the endocytosis of the antibody-drug conjugate into FGFR2-positive cells. Aprutumab can be used for the research of FGFR2-positive solid tumors, including studies on gastric cancer and triple-negative breast cancer.

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  • Pureté: 99.00%
  • CAS No.: 1634620-63-5
  • Masse moléculaire:144.6 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Aprutumab
  • Experimental Validation Results for Aprutumab
  • Aprutumab Chemical Structure
    Aprutumab Chemical Structure
CAS No.: 1634620-63-5
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Aprutumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Loaded Aprutumab on AHC2 biosensor, can bind FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78131) with an affinity constant of 1.819E-08 M as determined in BLI assay.

  • Aprutumab Chemical Structure
    1/16
  • Aprutumab
  • Loaded Aprutumab on AHC2 biosensor, can bind FGFR-2 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78131) with an affinity constant of 1.819E-08 M as determined in BLI assay.