Cephalexin (lysine)
Based on 9 publication(s) in Google Scholar
Cephalexin (Cefalexin) lysine is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin lysine has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin lysine targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin lysine is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al.
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- CAS No.: 53950-14-4
- Formule: C22H31N5O6S
- Masse moléculaire:493.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cephalexin (lysine)
More- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Chemosphere. 2021 Dec:285:131417. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
- J Med Chem. 2021 Oct 14;64(19):14344-14357. [Abstract]
- Infect Immun. 2018 May 22;86(6). pii: e00090-18. [Abstract]
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- University of Texas. 2025.
- bioRxiv. 2024 May 10.
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Activité biologique
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β-lactam |
Cephalexin lysine (10 μg/mL) disrupts polymer peptidoglycan (PG) biogenesis by inactivating enzymes called penicillin-binding proteins (PBPs)[1]. Cephalexin lysine inhibits a broad spectrum of grampositive and gram-negative organisms with MIC values of 2, 2, 2, 2, 4, 4.4 and 5.7 μg/mL for Bacillus anthracis, Edwardsiella taFda, Vibrio cholera, Pasteurella multocida, Edwardsiella tarda, Alcaligenes sp and Proteus rettgeri, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss-Webster mice with infected bacterial[2]
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Dosage:0-50 mg/kg
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Administration:Oral administration; for 3.5 hours
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Result:Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice.
Chemical Information
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CAS No. 53950-14-4
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Masse moléculaire 493.58
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Formule C22H31N5O6S
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SMILES
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O.N[C@H](C(O)=O)CCCCN
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Synonyms
Cefalexin (lysine); Cephacillin (lysine)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482 -
J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Chemosphere
Insights into the degradation mechanisms and pathways of cephalexin during homogeneous and heterogeneous photo-Fenton processes. [Abstract]2021 Dec:285:131417. PMID: 34246101 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
J Med Chem
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. [Abstract]2021 Oct 14;64(19):14344-14357. PMID: 34547896 -
Infect Immun
Identification and Characterization of the Neisseria gonorrhoeae MscS-Like Mechanosensitive Channel. [Abstract]2018 May 22;86(6). pii: e00090-18. PMID: 29581189 -
Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
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Pureté et documentation
Références
[1]. Cho H, et, al. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cell. 2014 Dec 4;159(6):1300-11. [Content Brief]
[2]. Buck RE, et, al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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