COX-2-IN-14
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice.
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- CAS No.: 2428387-48-6
- Formule: C18H18N4O6
- Masse moléculaire:386.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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COX-2 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | CC50 |
<100 μM
Compound: 2a
|
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32503692] |
| L929 | CC50 |
257.42 μM
Compound: 2a
|
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32503692] |
Chemical Information
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CAS No. 2428387-48-6
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Masse moléculaire 386.36
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Formule C18H18N4O6
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SMILES
CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)