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Cat. No.: HY-163509

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COX-2-IN-43

COX-2-IN-43 (Compound MYM4) is a COX-2 inhibitor (IC₅₀: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis.

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CAS No.: 1023524-40-4
Formule: C₁₈H₁₁Cl₂F₃N₂O₃
Masse moléculaire:431.19

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

COX-2-IN-43 Chemical Structure

CAS No.: 1023524-40-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

COX-1

0.983 μM (IC₅₀)

COX-2

0.247 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform COX :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	10.22 μM Compound: MYM4	Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HEK-293T	IC₅₀	216.97 μM Compound: MYM4	Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against HEK293T cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HeLa	IC₅₀	1.57 μM Compound: MYM4	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
Hep 3B2	IC₅₀	4.84 μM Compound: MYM4	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
HepG2	IC₅₀	29.174 μM Compound: MYM4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
LX-2	IC₅₀	20.01 μM Compound: MYM4	Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human LX2 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]
MCF7	IC₅₀	20.72 μM Compound: MYM4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay	[PMID: 38626522]

In Vitro

COX-2-IN-43 shows antiproliferative effects against CaCo-2, Hep3B, and HeLa cancer cell lines, with IC₅₀ values of 10.22, 4.84, and 1.57 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1023524-40-4
Masse moléculaire 431.19
Formule C₁₈H₁₁Cl₂F₃N₂O₃
SMILES

CC1=C(C(NC2=CC=C(C=C2)OC(F)(F)F)=O)C(C3=C(C=CC=C3Cl)Cl)=NO1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hawash M, et al. Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling. Eur J Med Chem. 2024 Apr 15;271:116397. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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COX-2-IN-43

Voir tous les produits spécifiques à Isoform COX

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

COX-2-IN-43 Related Classifications

HY-163509 Related Classifications