Gangaleoidin
Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer.
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- CAS No.: 55365-63-4
- Formule: C18H14Cl2O7
- Masse moléculaire:413.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | Inhibition |
15.0060 %
Compound: GANGALEOIDIN
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Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
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[PMID: 23571415] |
| CHO | Inhibition |
4.09271 %
Compound: GANGALEOIDIN
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Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
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[PMID: 23571415] |
Gangaleoidin (30 μM; 24-72 h) inhibits proliferation of FOXM1-overexpressing MDA-MB-231 and MCF-7 breast cancer cell MDA-MB-231 and MCF-7[1].
Gangaleoidin (30 μM; 24 h) downregulates mRNA expression of FOXM1c and CCNB1, but not CDC25b, in MDA-MB-231 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 and MCF-7 cells
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Concentration:30 μM
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Incubation Time:24, 36, 72 h
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Result:Significantly reduced relative cell viability in both MDA-MB-231 and MCF-7 cells.
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Cell Line:FOXM1-overexpressing MDA-MB-231 breast cancer cell line
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Concentration:30 μM
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Incubation Time:24 h
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Result:Significantly reduced mRNA expression of FOXM1c (autoregulated FOXM1 isoform) and the FOXM1 downstream target gene CCNB1.
Did not significantly affect expression of CDC25b.
Chemical Information
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CAS No. 55365-63-4
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Masse moléculaire 413.21
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Formule C18H14Cl2O7
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SMILES
O=C1OC2=C(OC3=C(C(O)=C(C(C)=C13)Cl)Cl)C(C)=C(C(OC)=O)C(OC)=C2
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Structure Classification
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Initial Source
Lecanora chlarotera
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lee MY, et al. Development of a FOXM1-DBD Binding Assay for High-Throughput Screening Using TR-FRET Assay. Biol Pharm Bull. 2021;44(10):1484-1491. [Content Brief]
[2]. Tuovinen V, et al. Tremella macrobasidiata and Tremella variae have abundant and widespread yeast stages in Lecanora lichens. Environ Microbiol. 2021 May;23(5):2484-2498. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gangaleoidin Related Classifications
HY-N19821 Related Classifications
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