55365-63-4
55365-63-4
Chemical Structure
Gangaleoidin
- CAS No.: 55365-63-4
- Formula:C18H14Cl2O7
- Molecular Weight:413.21
InChIKey: RPHAAJGBADUATP-UHFFFAOYSA-N
SMILES: O=C1OC2=C(OC3=C(C(O)=C(C(C)=C13)Cl)Cl)C(C)=C(C(OC)=O)C(OC)=C2
Biological Activity: Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer[1][2].
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Gangaleoidin | Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer. | |||||||||||||||||||||
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References
- [1]. Lee MY, et al. Development of a FOXM1-DBD Binding Assay for High-Throughput Screening Using TR-FRET Assay. Biol Pharm Bull. 2021;44(10):1484-1491. [Content Brief]
- [2]. Tuovinen V, et al. Tremella macrobasidiata and Tremella variae have abundant and widespread yeast stages in Lecanora lichens. Environ Microbiol. 2021 May;23(5):2484-2498. [Content Brief]
