2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Gangaleoidin

Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer.

For research use only. We do not sell to patients.

Gangaleoidin

Gangaleoidin Chemical Structure

CAS No. : 55365-63-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Gangaleoidin Related Antibodies

Top Publications Citing Use of Products

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer[1][2].

In Vitro

Gangaleoidin (30 μM; 24-72 h) inhibits proliferation of FOXM1-overexpressing MDA-MB-231 and MCF-7 breast cancer cell MDA-MB-231 and MCF-7[1].
Gangaleoidin (30 μM; 24 h) downregulates mRNA expression of FOXM1c and CCNB1, but not CDC25b, in MDA-MB-231 breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gangaleoidin Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231 and MCF-7 cells
Concentration: 30 μM
Incubation Time: 24, 36, 72 h
Result: Significantly reduced relative cell viability in both MDA-MB-231 and MCF-7 cells.

Real Time qPCR[1]

Cell Line: FOXM1-overexpressing MDA-MB-231 breast cancer cell line
Concentration: 30 μM
Incubation Time: 24 h
Result: Significantly reduced mRNA expression of FOXM1c (autoregulated FOXM1 isoform) and the FOXM1 downstream target gene CCNB1.
Did not significantly affect expression of CDC25b.
Molecular Weight

413.21

Formula

C18H14Cl2O7
CAS No.
SMILES

O=C1OC2=C(OC3=C(C(O)=C(C(C)=C13)Cl)Cl)C(C)=C(C(OC)=O)C(OC)=C2
Structure Classification
Initial Source

Lecanora chlarotera
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Gangaleoidin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gangaleoidin55365-63-4DNA/RNA SynthesisFOXM1cLecanora chlorotera Nyl.MCF-7CDC25bbreast cancerFOXM1MDA-MB-231FOXM1-overexpressing breast cancer cellsDNA-binding domainCCNB1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Gangaleoidin
Cat. No.:
HY-N19821
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.