MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.
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- CAS No.: 110044-82-1
- Formule: C20H37N3O4
- Masse moléculaire:383.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MG-101 (GMP) (0-26 μM; 24 h) affects the growth of colon cancer HCT116 cells[1]. MG-101 (GMP) (0-26 μM; 24 h) induces apoptosis of various cancer cells[1]. MG-101 (GMP) (0-26 μM; 24 h) induces Bax-dependent apoptosis in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cell line
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Concentration:0-26 μM
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Incubation Time:24 hours
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Result:Anchorage-independently and significantly decreased the viability of HCT116 cells.
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Cell Line:HCT116, RKO, SW480 and HepG2 cell lines
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Concentration:0-26 μM
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Incubation Time:24 hours
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Result:Dose-dependently decreased the concentration of pro-caspase 3 and increased the concentration of cleaved-PARP in HCT116 cells. Induced apoptosis of HCT116, RKO, SW480 and HepG2 cells.
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Cell Line:HCT116, HCT116/p53-/- and HCT116/Bax-/- cell lines
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Concentration:0-26 μM
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Incubation Time:24 hours
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Result:Induced apoptosis via a Bax-dependent manner, but not via a p53-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice with HCT116 cells injection[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; 10 mg/kg once daily; for 15 days
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Result:Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
Chemical Information
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CAS No. 110044-82-1
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Masse moléculaire 383.53
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Formule C20H37N3O4
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SMILES
O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C
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Synonyms
Calpain inhibitor I (GMP); Ac-LLnL-CHO (GMP); ALLN (GMP)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MG-101 (GMP) Related Classifications
HY-18964G Related Classifications
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