Nampt activator-2
Based on 1 Customer Validation
Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).
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- Pureté: 98.79%
- CAS No.: 2237268-90-3
- Formule: C17H15ClN4O3S
- Masse moléculaire:390.84
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse[1]
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Dosage:1 mg/kg iv and 10 mg/kg po
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Administration:IV, PO; once (Pharmacokinetic Analysis)
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Result:Pharmacokinetic Parameters of Nampt activator-2 in mouse[1].
IV (1 mg/kg) PO (10 mg/kg) Cmax (ng/mL) 9550 AUC0-24 (ng/mL∗h) 54463 t1/2 (h) 3.2 CL (mL/min/kg) 3 Vd (L/kg) 0.61 F (%) 80
Chemical Information
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CAS No. 2237268-90-3
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Appearance Solid
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Masse moléculaire 390.84
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Formule C17H15ClN4O3S
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Color Off-white to light yellow
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SMILES
O=C(NCC1=CNN=C1)NC2=CC=C(S(=O)(C3=CC=C(C=C3)Cl)=O)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 250 mg/mL (639.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5586 mL | 12.7930 mL | 25.5859 mL | 63.9648 mL |
| 5 mM | 0.5117 mL | 2.5586 mL | 5.1172 mL | 12.7930 mL | |
| 10 mM | 0.2559 mL | 1.2793 mL | 2.5586 mL | 6.3965 mL | |
| 15 mM | 0.1706 mL | 0.8529 mL | 1.7057 mL | 4.2643 mL | |
| 20 mM | 0.1279 mL | 0.6396 mL | 1.2793 mL | 3.1982 mL | |
| 25 mM | 0.1023 mL | 0.5117 mL | 1.0234 mL | 2.5586 mL | |
| 30 mM | 0.0853 mL | 0.4264 mL | 0.8529 mL | 2.1322 mL | |
| 40 mM | 0.0640 mL | 0.3198 mL | 0.6396 mL | 1.5991 mL | |
| 50 mM | 0.0512 mL | 0.2559 mL | 0.5117 mL | 1.2793 mL | |
| 60 mM | 0.0426 mL | 0.2132 mL | 0.4264 mL | 1.0661 mL | |
| 80 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7996 mL | |
| 100 mM | 0.0256 mL | 0.1279 mL | 0.2559 mL | 0.6396 mL |
Nampt activator-2 Related Classifications
HY-148822 Related Classifications
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