1. Metabolic Enzyme/Protease
  2. Nampt

CB30865 (Synonyms: ZM 242421)

Cat. No.: HY-14373 Purity: 98.33%
Handling Instructions

CB30865(ZM 242421) is a potent inhibitor of Nampt , an enzyme present in the NAD biosynthetic pathway.

For research use only. We do not sell to patients.

CB30865 Chemical Structure

CB30865 Chemical Structure

CAS No. : 206275-15-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 390 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 343 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 443 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1195 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Related Small Molecules:

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  • Technical Information

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  • References

Description

CB30865(ZM 242421) is a potent inhibitor of Nampt , an enzyme present in the NAD biosynthetic pathway. IC50 value: Target: Nampt Cancer cells develop dependence on Nampt due to increased energy requirements and the elevated activity of NAD consuming enzymes such as sirtuins and mono and poly(ADP-ribose) polymerases (PARPs). These findings suggest new chemical starting points for Nampt inhibitors and further implicate this enzyme as a target in cancer.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9365 mL 9.6826 mL 19.3652 mL
5 mM 0.3873 mL 1.9365 mL 3.8730 mL
10 mM 0.1937 mL 0.9683 mL 1.9365 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

516.39

Formula

C₂₆H₂₂BrN₅O₂

CAS No.

206275-15-2

SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(N=C(C)NC4=O)C=C3Br)CC#C)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
CB30865
Cat. No.:
HY-14373
Quantity:

CB30865

Cat. No.: HY-14373