1. Metabolic Enzyme/Protease
  2. NAMPT
  3. CB30865

CB30865 (Synonyms: ZM 242421)

Cat. No.: HY-14373 Purity: 98.05%
Handling Instructions

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range).

For research use only. We do not sell to patients.

CB30865 Chemical Structure

CB30865 Chemical Structure

CAS No. : 206275-15-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 390 In-stock
Estimated Time of Arrival: December 31
5 mg USD 343 In-stock
Estimated Time of Arrival: December 31
10 mg USD 443 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1195 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC50 values in the 1-10 nM range)[1][2].

In Vitro

CB30865 exhibits cytotoxicity due to NAD reduction via Nampt inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.39

Formula

C₂₆H₂₂BrN₅O₂

CAS No.
SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(N=C(C)NC4=O)C=C3Br)CC#C)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9365 mL 9.6826 mL 19.3652 mL
5 mM 0.3873 mL 1.9365 mL 3.8730 mL
10 mM 0.1937 mL 0.9683 mL 1.9365 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CB30865ZM 242421CB 30865CB-30865ZM242421ZM-242421NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorcytotoxic NamptNADbiosyntheticpathwaycellcyclearrestInhibitorinhibitorinhibit

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Product Name:
CB30865
Cat. No.:
HY-14373
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