CB30865 (Synonyms: ZM 242421)

Cat. No.: HY-14373 Purity: 98.05%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range).

For research use only. We do not sell to patients.

CB30865 Chemical Structure

CAS No. : 206275-15-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 284	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 284	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 890	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

CB30865 exhibits cytotoxicity due to NAD reduction via Nampt inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.39

Formula

C₂₆H₂₂BrN₅O₂

CAS No.

206275-15-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(N=C(C)NC4=O)C=C3Br)CC#C)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9365 mL	9.6826 mL	19.3652 mL
5 mM	0.3873 mL	1.9365 mL	3.8730 mL
10 mM	0.1937 mL	0.9683 mL	1.9365 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.05%

Select Batch:

Data Sheet (275 KB) SDS (0 KB)

COA (254 KB) LCMS (121 KB)

Handling Instructions (2659 KB)

References

[1]. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. [Content Brief]

[2]. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9365 mL	9.6826 mL	19.3652 mL	48.4130 mL
	5 mM	0.3873 mL	1.9365 mL	3.8730 mL	9.6826 mL
	10 mM	0.1937 mL	0.9683 mL	1.9365 mL	4.8413 mL
	15 mM	0.1291 mL	0.6455 mL	1.2910 mL	3.2275 mL
	20 mM	0.0968 mL	0.4841 mL	0.9683 mL	2.4207 mL
	25 mM	0.0775 mL	0.3873 mL	0.7746 mL	1.9365 mL
	30 mM	0.0646 mL	0.3228 mL	0.6455 mL	1.6138 mL
	40 mM	0.0484 mL	0.2421 mL	0.4841 mL	1.2103 mL
	50 mM	0.0387 mL	0.1937 mL	0.3873 mL	0.9683 mL
	60 mM	0.0323 mL	0.1614 mL	0.3228 mL	0.8069 mL

CB30865 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks