PLK1-IN-9
PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model.
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- CAS No.: 893772-67-3
- Formule: C12H7F3N4O2
- Masse moléculaire:296.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Chemical Information
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CAS No. 893772-67-3
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Masse moléculaire 296.20
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Formule C12H7F3N4O2
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SMILES
CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLK1-IN-9 Related Classifications
HY-W276819 Related Classifications
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