893772-67-3
Chemical Structure
PLK1-IN-9
- CAS No.: 893772-67-3
- Formula:C12H7F3N4O2
- Molecular Weight:296.20
IUPAC Name: 10-methyl-7-(trifluoromethyl)benzo[g]pteridine-2,4(3H,10H)-dione
InChIKey: KCDITQBGZLRTBX-UHFFFAOYSA-N
SMILES: CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2
Biological Activity: PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1].
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PLK1-IN-9 | PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model. | |||||||||||||||||||||
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Keywords
