SphK2-IN-4
SphK2-IN-4 is a selective SphK2 inhibitor (IC50=6.2 μM) with extremely low activity against SphK1 (IC50 > 50 μM). SphK2-IN-4 exhibits broad-spectrum antiproliferative activity against colorectal cancer cells and induces apoptosis.
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- CAS No.: 3082221-87-9
- Formule: C21H27F3N2O5S
- Masse moléculaire:476.51
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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SphK2 |
SphK2-IN-4 (Q25) potently inhibits the proliferation of LOVO, SW480, SW620, and HT-29 human colorectal cancer cells with IC50 values ranging from 6.41 μM to 8.09 μM after 72 h of incubation[1].
SphK2-IN-4 (6 μM; 48 h) induces S-phase cell cycle arrest in SW480 human colorectal cancer cells after 48 h of treatment at 6 μM[1].
SphK2-IN-4 (3-6 μM; 48 h) dose-dependently induces apoptosis in SW480 human colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LOVO, SW480, SW620, HT-29 human colorectal cancer cell lines
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Concentration:Serial concentrations
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Incubation Time:72 h
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Result:Inhibited proliferation of LOVO cells with an IC50 of 8.09 μM.
Inhibited proliferation of SW480 cells with an IC50 of 7.77 μM.
Inhibited proliferation of SW620 cells with an IC50 of 7.38 μM.
Inhibited proliferation of HT-29 cells with an IC50 of 6.41 μM.
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Cell Line:SW480 human colorectal cancer cells
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Concentration:3-6 μM
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Incubation Time:48 h
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Result:Significantly increased the proportion of SW480 cells in the S-phase compared to the control group at 6 μM.
Induced S-phase cell cycle arrest at 6 μM.
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Cell Line:SW480 human colorectal cancer cells
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Concentration:3-6 μM
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Incubation Time:48 h
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Result:Increased early apoptotic cells to 10.9% and late apoptotic cells to 12.2% at 6 μM, compared to 1.62% early and 0.02% late apoptotic cells in the control group.
Demonstrated dose-dependent induction of apoptosis.
Resulted in 23.1% total apoptotic cells at 6 μM after 48 h.
Chemical Information
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CAS No. 3082221-87-9
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Masse moléculaire 476.51
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Formule C21H27F3N2O5S
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SMILES
CCCCCOC1=CC=C(CC/C=C2SC(N(CCN)C\2=O)=O)C=C1.O=C(O)C(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SphK2-IN-4 Related Classifications
HY-183338 Related Classifications
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