country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-153504

Copy Link Print Information

TACE-IN-1

TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1219812-22-2
Formule: C₂₆H₂₆N₄O₇
Masse moléculaire:506.52

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TACE-IN-1 Chemical Structure

CAS No.: 1219812-22-2

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform TNF Receptor :

In Vitro

TACE-IN-1 (1 h pre-incubation; 3.5 h post-LPS addition) inhibits TNF-α production in human whole blood with an IC₅₀ of 281 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	AUC
Rat^[1]	10 mg/kg	p.o.	74 %	13.1 μM·h
Monkey^[1]	3 mg/kg	p.o.	92 %	/
Dog^[1]	3 mg/kg	p.o.	72 %	/
Rat^[1]	100 mg/kg	p.o.	/	210 μM·h
Rat^[1]	300 mg/kg	p.o.	/	780 μM·h
Rat^[1]	500 mg/kg	p.o.	/	1450 μM·h

Chemical Information

CAS No. 1219812-22-2
Masse moléculaire 506.52
Formule C₂₆H₂₆N₄O₇
SMILES

C([C@@]1(C(=O)N(COC(C(C)(C)C)=O)C(=O)N1)C2=CC=3C(O2)=CC=CN3)N4C(=O)C=5C(C4)=CC=C(OC)C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Tong L, et al. Development of a prodrug of hydantoin based TACE inhibitor. Bioorg Med Chem Lett. 2017;27(16):3704-3708. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

TACE-IN-1

Voir tous les produits spécifiques à Isoform TNF Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TACE-IN-1 Related Classifications

HY-153504 Related Classifications