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Cat. No.: HY-106918

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Tivirapine

(Synonyms: R86183; TIBO R 86183)

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC₅₀ value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT.

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CAS No.: 137332-54-8
Formule: C₁₆H₂₀ClN₃S
Masse moléculaire:321.87

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tivirapine Chemical Structure

CAS No.: 137332-54-8

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC₅₀ value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
C8166	CC₅₀	50 μM Compound: 8-CITIBO	Cytotoxicity against C8166 cells by MTT assay Cytotoxicity against C8166 cells by MTT assay	[PMID: 16279773]
C8166	EC₅₀	0.03 μM Compound: 8-ClTIBO	Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay	[PMID: 19170521]
C8166	EC₅₀	0.03 μM Compound: 2 (8-CITIBO)	Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells	[PMID: 11462972]
C8166	EC₅₀	0.03 μM Compound: 8-CITIBO	Inhibition of HIV1-3B replication in C8166 cells Inhibition of HIV1-3B replication in C8166 cells	[PMID: 16279773]
C8166	IC₅₀	50 μM Compound: 2 (8-CITIBO)	Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound) Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)	[PMID: 11462972]
MT2	EC₅₀	14 nM Compound: 2, 8-Cl-TIBO	Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay	[PMID: 23380374]
MT2	IC₅₀	>100 nM Compound: 2, 8-Cl-TIBO	Cytotoxicity against human MT2 cells after 5 days by MTT assay Cytotoxicity against human MT2 cells after 5 days by MTT assay	[PMID: 23380374]
MT4	EC₅₀	0.0043 μM Compound: 9, R86183	Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells	[PMID: 19632850]
MT4	EC₅₀	4.6 nM Compound: 3	Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells	[PMID: 15771411]
MT4	IC₅₀	0.0043 μM Compound: 6a	Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1 Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1	[PMID: 7877144]

Chemical Information

CAS No. 137332-54-8
Masse moléculaire 321.87
Formule C₁₆H₂₀ClN₃S
SMILES

ClC(C1=C2N3C[C@@H](N(C1)C/C=C(C)\C)C)=CC=C2NC3=S
Synonyms

R86183; TIBO R 86183
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ding J, et al. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol. 1995 May;2(5):407-15. [Content Brief]

[2]. Zhou Z, et al. Relative free energy of binding and binding mode calculations of HIV-1 RT inhibitors based on dock-MM-PB/GS. Proteins. 2004 Nov 15;57(3):493-503. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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Tivirapine

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Tivirapine Related Classifications

HY-106918 Related Classifications