2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. CA1001

CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

For research use only. We do not sell to patients.

CA1001

CA1001 Chemical Structure

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CA1001 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.

Species Reactivity

Human
In Vitro

CA1001 exhibits potent anti-tumor activity in melanoma cell lines[1].
CA1001 exerts a synergistic effect when combined with immune checkpoint inhibitors, significantly enhancing tumor regression in melanoma cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CA1001 Related Antibodies
In Vivo

CA1001 (1 mg/kg) attenuates acute responses in formalin-induced hyperalgesic mice[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly reverses mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly increases paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: i.p., once
Result: Significantly reversed mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h.
Animal Model: Rat[2]
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/k
Administration: i.p., once
Result: Significantly increased paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia.
Gene ID

2811  [NCBI]

Accession

P07359
Target

CD42b/GP1BA
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[CA1001]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CA1001 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA1001CA 1001CA-1001Opioid ReceptorZNF74 inhibitor/κ/δ dual opioid receptor agonistmelanoma cell linesRatmelanomamechanical hyperalgesianeuropathic paininflammatory arthritis painInhibitorinhibitorinhibit

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