6-Phosphogluconic acid trisodium
Based on 1 Customer Validation
6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite.
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- Reinheit: 99.96%
- CAS. Nr.: 53411-70-4
- Formel: C6H10Na3O10P
- Molecular Weight:342.08
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Chemical Information
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Biologische Aktivität
phosphoglucose isomerase[1]
6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 53411-70-4
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Appearance Solid
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Molecular Weight 342.08
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Formel C6H10Na3O10P
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Color White to off-white
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SMILES
O=C(O[Na])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O[Na])(O[Na])=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
H2O : 116.67 mg/mL (341.06 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [Content Brief]
[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9233 mL | 14.6165 mL | 29.2329 mL | 73.0823 mL |
| 5 mM | 0.5847 mL | 2.9233 mL | 5.8466 mL | 14.6165 mL | |
| 10 mM | 0.2923 mL | 1.4616 mL | 2.9233 mL | 7.3082 mL | |
| 15 mM | 0.1949 mL | 0.9744 mL | 1.9489 mL | 4.8722 mL | |
| 20 mM | 0.1462 mL | 0.7308 mL | 1.4616 mL | 3.6541 mL | |
| 25 mM | 0.1169 mL | 0.5847 mL | 1.1693 mL | 2.9233 mL | |
| 30 mM | 0.0974 mL | 0.4872 mL | 0.9744 mL | 2.4361 mL | |
| 40 mM | 0.0731 mL | 0.3654 mL | 0.7308 mL | 1.8271 mL | |
| 50 mM | 0.0585 mL | 0.2923 mL | 0.5847 mL | 1.4616 mL | |
| 60 mM | 0.0487 mL | 0.2436 mL | 0.4872 mL | 1.2180 mL | |
| 80 mM | 0.0365 mL | 0.1827 mL | 0.3654 mL | 0.9135 mL | |
| 100 mM | 0.0292 mL | 0.1462 mL | 0.2923 mL | 0.7308 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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