ALizarin complexone dihydrate
ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
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- CAS. Nr.: 455303-00-1
- Formel: C19H19NO10
- Molecular Weight:421.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Alizarin complexone inhibits reverse transcriptase activity of RAV-2 , HIV-1, and RSV, with IC50 values of 3.8 μg/mL, 45 μg/mL and 100 μg/mL, respectively[1].
Alizarin complexone (0.1%; 1.5-2.5 h) stains mineralized bone matrix in medaka larvae, enabling visualization of vertebral body mineralization and assessment of Bisphosphonate-induced inhibition of osteoclast-mediated bone resorption in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Alizarin complexone (0.75 mg/mL, 10 μL, intra-articular injection) detects increased permeability from articular cartilage to subchondral bone and enhanced periosteal penetration in 11-12-week-old male C57BL/6J mice with DMM-induced early osteoarthritis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 455303-00-1
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Molecular Weight 421.35
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Formel C19H19NO10
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SMILES
O=C(CN(CC(C=C1C2=O)=C(C(O)=C1C(C3=C2C=CC=C3)=O)O)CC(O)=O)O.O.O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15(3):205-216. [Content Brief]
[2]. Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper(II)-chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79. [Content Brief]
[3]. Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9(2):155-63. [Content Brief]
[4]. Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6(11):539-554. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ALizarin complexone dihydrate Related Classifications
HY-W320523 Related Classifications
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